Medal and Decoration
See also : Russia 1700-1900 Nobel medals Sciences Sciences from 1800 Inventions Medicine Sport memorabilia Sport memorabilia II Sport rewards and medals
Chronology : 1790-1799 1917 1945
External link : list of auction results of the Victoria Cross.
Chronology : 1790-1799 1917 1945
External link : list of auction results of the Victoria Cross.
1797 The Order of St. Andrew
2012 SOLD 1.73 M€ including premium
The order of St. Andrew was created by Peter the Great in imitation of the English orders. This system enabling to distinguish the members of the Imperial family and the grand courtiers was widely used by the Romanov.
In 1797, the new Tsar Paul I gave its official status to this order, accompanied by some charitable duties. The insignia consisted of a star, a large collar and a jewel constituted by a cross of St Andrew resting on the two-headed eagle under a crown.
On June 20 in Paris, Damien Libert sells a complete set of Knight of the Order of St. Andrew made in the period of the reforms of Paul I. The recipient is not identified but he was certainly a French aristocrat involved in the Russian army or at the court: the name of the fifth duc de Richelieu is advanced in the catalog with a good probability.
The cross and the 23 links of the collar are crafted in gold and enamel. The star is made of silver sequins. The lower estimate is announced by La Gazette Drouot at € 400K and at € 500K by the press release. Let us rather state that it is difficult to predict the price of this very rare complete set.
Only members of the Imperial family could crimp their badges of St. Andrew with precious stones. The cross, also from the time of Paul I, sold £ 2.7 million including premium by Sotheby's on 12 June 2008 was exceptional: it was set with 45 carats of diamonds and the eagle eyes were rubies.
POST SALE COMMENT
This set was worth more than its estimate, of course, and less than the Imperial jewel that I had taken as a reference. The result, € 1.73 million including premium, is very satisfactory.
In 1797, the new Tsar Paul I gave its official status to this order, accompanied by some charitable duties. The insignia consisted of a star, a large collar and a jewel constituted by a cross of St Andrew resting on the two-headed eagle under a crown.
On June 20 in Paris, Damien Libert sells a complete set of Knight of the Order of St. Andrew made in the period of the reforms of Paul I. The recipient is not identified but he was certainly a French aristocrat involved in the Russian army or at the court: the name of the fifth duc de Richelieu is advanced in the catalog with a good probability.
The cross and the 23 links of the collar are crafted in gold and enamel. The star is made of silver sequins. The lower estimate is announced by La Gazette Drouot at € 400K and at € 500K by the press release. Let us rather state that it is difficult to predict the price of this very rare complete set.
Only members of the Imperial family could crimp their badges of St. Andrew with precious stones. The cross, also from the time of Paul I, sold £ 2.7 million including premium by Sotheby's on 12 June 2008 was exceptional: it was set with 45 carats of diamonds and the eagle eyes were rubies.
POST SALE COMMENT
This set was worth more than its estimate, of course, and less than the Imperial jewel that I had taken as a reference. The result, € 1.73 million including premium, is very satisfactory.
>1797 What sort of Badge was worn at the Imperial Court of Russia
2008 SOLD 2.7 M£ including premium
All observers say and assess that what comes from Russia is in the top fashion of the time being, and that greatly interested Russian buyers are keen to reconstitute their past.
We also know that everything coming from imperial origines of all countries make collectors and scholars dreaming.
The brooch (the word used in English by Sotheby's is badge), which is lot 540 of the sale of Sotheby's in London on June 12, comes from the crown jewels of Imperial Russia. In imposing size (13 x 9 cm, 160 grams), its low estimate of 400 K£ is even less surprising when we know that it is covered with 45 carats of diamonds.
Its drawing, very fine, has two bodies: the main part is an eagle with two heads and with wings and tail deployed. This one is partly covered by a cross of St Andrew with the image of the saint. Over it, there is the beautiful image of the imperial crown. All of this is in diamonds except the eyes of the eagle which are rubies and beaks and claws which are gold.
The jewel was made around 1800 as a decoration of the Order of St. Andrew. It was a privilege of the tsar's family to wear this type of decorations in the great occasions of the State. The descent from that piece is known: given by the Imperial family to the ducal family of Oldenburg, it returned in 1890 to Empress Maria Feodorovna, who wore it.
The estimate is very open, with a high estimate at 600 K £. But is there really a price for such a treasure?
POST SALE COMMENT
The treasure has now a price: £ 2.7 million charge included.
It is an excellent result which will refer.
We also know that everything coming from imperial origines of all countries make collectors and scholars dreaming.
The brooch (the word used in English by Sotheby's is badge), which is lot 540 of the sale of Sotheby's in London on June 12, comes from the crown jewels of Imperial Russia. In imposing size (13 x 9 cm, 160 grams), its low estimate of 400 K£ is even less surprising when we know that it is covered with 45 carats of diamonds.
Its drawing, very fine, has two bodies: the main part is an eagle with two heads and with wings and tail deployed. This one is partly covered by a cross of St Andrew with the image of the saint. Over it, there is the beautiful image of the imperial crown. All of this is in diamonds except the eyes of the eagle which are rubies and beaks and claws which are gold.
The jewel was made around 1800 as a decoration of the Order of St. Andrew. It was a privilege of the tsar's family to wear this type of decorations in the great occasions of the State. The descent from that piece is known: given by the Imperial family to the ducal family of Oldenburg, it returned in 1890 to Empress Maria Feodorovna, who wore it.
The estimate is very open, with a high estimate at 600 K £. But is there really a price for such a treasure?
POST SALE COMMENT
The treasure has now a price: £ 2.7 million charge included.
It is an excellent result which will refer.
1917 Victoria Cross of Vice-Admiral Gordon Campbell
2017 SOLD for £ 840K including premium by Morton and Eden
Morton and Eden are delighted to announce the sale of the Victoria Cross & DSO** Group of 11 to Vice-Admiral Gordon Campbell, sold today for £840,000 (with premium), a new world record for a Victoria Cross at auction. pic.twitter.com/WBWvxE8rbu
— Morton & Eden Ltd (@MortonandEden) November 23, 2017
1934 Liver and Anemia
2015 SOLD for $ 550K including premium
Medicine and pharmacy made significant progress by empirical experiments. The Nobel Prize in Physiology or Medicine highlights a long list of victories over previously incurable diseases. It was awarded in 1934 to Whipple, Minot and Murphy for their work on the diet of pernicious anemia.
The mechanism of the disease is not known when Whipple presumes that the liver has a role in it. He shows on dogs that the absorption of liver reverses the effects of an induced anemia. In 1926, Minot and Murphy use his results to prepare liver juice for patients showing syndromes of pernicious anemia. The disease is defeated.
The pharmaceutical story does not end at that point, fortunately. As early as 1928, another researcher who was not honored in the Nobel prize improved the diet by injecting liver extracts to the patient, avoiding him a daily swallow of a big quantity of liver food. In 1948, the cause of the pernicious anemia is identified as a deficiency of absorption by the intestine of a previously unidentified vitamin.
On September 21 in New York, Bonhams sells in one lot the Nobel medal and diploma awarded to George Minot along with various related documents, lot 46 estimated $ 200K.
One of these documents is particularly noteworthy. Minot suffered from a severe diabetes. He had been saved from death by the discovery of insulin in 1921. Frederick Banting wrote from Toronto to congratulate him on his Nobel and to comfort him by stating that good quality insulin is also available in Sweden.
I invite you to watch the video shared by Bonhams.
The mechanism of the disease is not known when Whipple presumes that the liver has a role in it. He shows on dogs that the absorption of liver reverses the effects of an induced anemia. In 1926, Minot and Murphy use his results to prepare liver juice for patients showing syndromes of pernicious anemia. The disease is defeated.
The pharmaceutical story does not end at that point, fortunately. As early as 1928, another researcher who was not honored in the Nobel prize improved the diet by injecting liver extracts to the patient, avoiding him a daily swallow of a big quantity of liver food. In 1948, the cause of the pernicious anemia is identified as a deficiency of absorption by the intestine of a previously unidentified vitamin.
On September 21 in New York, Bonhams sells in one lot the Nobel medal and diploma awarded to George Minot along with various related documents, lot 46 estimated $ 200K.
One of these documents is particularly noteworthy. Minot suffered from a severe diabetes. He had been saved from death by the discovery of insulin in 1921. Frederick Banting wrote from Toronto to congratulate him on his Nobel and to comfort him by stating that good quality insulin is also available in Sweden.
I invite you to watch the video shared by Bonhams.
1936 Olympic Gold for Jesse Owens
2013 SOLD 1.47 M$ including premium
The success of Jesse Owens at the Berlin Olympics in 1936 was not a surprise. Technically, he was one of the best sprinters of all time by a remarkable optimization of movement and an amazing sacrifice of pain during effort.
He won four prestigious events : 100 meters, 200 meters, long jump and within 4 x 100 meters team. This grandson of slaves who was born in Alabama became a hero for the whole African-American community and is still now one of the most popular symbols of the Nazi abuse.
On this last point, the reality is surprising. Hitler was willing to admit that Negroes had morphologic features that enabled them to win. Earlier in these games, the Chancellor had only congratulated German athletes. His advisers made him understand that it was a blunder and he therefore decided to stop contacting any winner.
Owens himself declared that Hitler had not been hostile to him. On the opposite, the champion sharply criticized the racial segregation in his own country, which will still go further for 32 years before being abolished.
One of the four gold medals of Jesse Owens is for sale by SCP Auctions. The online auction will close on December 7. It is not known which of his four wins is related to this award. His other three medals are not localized.
I invite you to play the video commented by Darren Rovell for the ESPN specialized sport channel.
POST SALE COMMENT
Very good result for this medal that was outstanding for both sporting feat and political significance: $ 1.47 million including premium.
He won four prestigious events : 100 meters, 200 meters, long jump and within 4 x 100 meters team. This grandson of slaves who was born in Alabama became a hero for the whole African-American community and is still now one of the most popular symbols of the Nazi abuse.
On this last point, the reality is surprising. Hitler was willing to admit that Negroes had morphologic features that enabled them to win. Earlier in these games, the Chancellor had only congratulated German athletes. His advisers made him understand that it was a blunder and he therefore decided to stop contacting any winner.
Owens himself declared that Hitler had not been hostile to him. On the opposite, the champion sharply criticized the racial segregation in his own country, which will still go further for 32 years before being abolished.
One of the four gold medals of Jesse Owens is for sale by SCP Auctions. The online auction will close on December 7. It is not known which of his four wins is related to this award. His other three medals are not localized.
I invite you to play the video commented by Darren Rovell for the ESPN specialized sport channel.
POST SALE COMMENT
Very good result for this medal that was outstanding for both sporting feat and political significance: $ 1.47 million including premium.
1944 Three Days in Normandy
2017 SOLD for CAD $ 660K including premium
The landing in Normandy is a success. Troop movements become a matter of life and death for both parties. Two German armies must pass a bottleneck on the Dives river. On August 19, 1944 Major D.V. Currie is ordered to take the hamlet of Saint-Lambert.
For this battle of tanks Currie has with him 75 soldiers of his reconnaissance squadron of the Canadian army and 55 Canadian infantry men. After three days of intense fighting the village is taken and the Germans surrender.
Through his intelligence of action and his personal involvement Currie was the Leonidas of this important battle. His timidity was transformed into an unfailing heroism during these three days without any rest. He will report that he only had one fear : "the possibility that I might not measure up to that which is asked of me". He received the Victoria Cross from the hands of the King on November 30, 1944.
The group of 9 medals of Major (later Lieutenant-Colonel) Currie including his Victoria Cross will be sold on September 27 by DNW (Dix Noonan Webb). The VC requires an export permit to leave Canada and the sale will be made in London UK in Canadian dollars. The group is estimated $ CAD 500K, lot 495. Here is the link to the press release.
On July 28, 2011, the group of medals of an Australian soldier also including a Victoria Cross was sold for A $ 1.16M including premium by Noble Numismatics. Also from the second world war the group of medals including the George Cross posthumously awarded to Violette Szabo was sold for £ 310K including premium by DNW on July 22, 2015.
For this battle of tanks Currie has with him 75 soldiers of his reconnaissance squadron of the Canadian army and 55 Canadian infantry men. After three days of intense fighting the village is taken and the Germans surrender.
Through his intelligence of action and his personal involvement Currie was the Leonidas of this important battle. His timidity was transformed into an unfailing heroism during these three days without any rest. He will report that he only had one fear : "the possibility that I might not measure up to that which is asked of me". He received the Victoria Cross from the hands of the King on November 30, 1944.
The group of 9 medals of Major (later Lieutenant-Colonel) Currie including his Victoria Cross will be sold on September 27 by DNW (Dix Noonan Webb). The VC requires an export permit to leave Canada and the sale will be made in London UK in Canadian dollars. The group is estimated $ CAD 500K, lot 495. Here is the link to the press release.
On July 28, 2011, the group of medals of an Australian soldier also including a Victoria Cross was sold for A $ 1.16M including premium by Noble Numismatics. Also from the second world war the group of medals including the George Cross posthumously awarded to Violette Szabo was sold for £ 310K including premium by DNW on July 22, 2015.
1945 The Decorations of a Gallant Australian
2011 SOLD for AUD 1.16M including premium
Created by Queen Victoria during the Crimean War, the Victoria Cross is considered as the highest military decoration of the Commonwealth. Honoring the bravery facing the enemy, it glorifies the acts of courage of soldiers whatever their rank in the army.
On September 6, 1945, Edward "Ted" Kenna, an Australian soldier aged 26, received this outstanding award for the capture of an enemy position in New Guinea.
According to the will of the hero, his medals are coming at auction. On July 28 in Melbourne, Noble Numismatics sells ten decorations of Kenna including his Victoria Cross, as a single lot estimated Aus $ 900K.
On July 24, 2006 in Sydney, Bonhams and Goodman had sold Aus $ 1M before fees the Victoria Cross awarded posthumously to an Australian captain after the battle of Gallipoli in 1915.
POST SALE COMMENT
Very good result: Aus $ 1 million before fees. Whereas the Victoria Cross is the centerpiece of this set, we can consider that the price obtained in 2006 on the other cross was equaled.
On September 6, 1945, Edward "Ted" Kenna, an Australian soldier aged 26, received this outstanding award for the capture of an enemy position in New Guinea.
According to the will of the hero, his medals are coming at auction. On July 28 in Melbourne, Noble Numismatics sells ten decorations of Kenna including his Victoria Cross, as a single lot estimated Aus $ 900K.
On July 24, 2006 in Sydney, Bonhams and Goodman had sold Aus $ 1M before fees the Victoria Cross awarded posthumously to an Australian captain after the battle of Gallipoli in 1915.
POST SALE COMMENT
Very good result: Aus $ 1 million before fees. Whereas the Victoria Cross is the centerpiece of this set, we can consider that the price obtained in 2006 on the other cross was equaled.
1962 The Invention of the Molecular Biology
2014 SOLD for $ 4.8M including premium
The birth of molecular biology is the result of a multidisciplinary cooperation between chemists, physicists and biologists. The existence of nucleic acids in the cell nuclei had been identified in the nineteenth century. From 1939, advances in micro-radiography X gave hope to understand the structure of these molecules.
Scientists had identified two types of acids, RNA (ribonucleic acid) in the cytoplasm of the cell and DNA (deoxyribonucleic acid) in the chromosomes. They appreciated that these acids held the key to the functioning of life.
Two British laboratories of crystallography worked collaboratively. Francis Crick, assisted by the young US doctor James D. Watson, was at Cambridge. In London, Maurice Wilkins was assisted by Rosalind Franklin who perfected the techniques of observation and realized the radiograms. The untimely cancer of Rosalind Franklin is probably due to an excess of radiation dose.
The single helix of RNA structure and the two strands of DNA were among the first discoveries. In 1953, Watson understood that the shapes of the elements of the two DNA strands were identical although these elements were different. Crick and Watson immediately developed the model of the double helix, which was the biggest breakthrough of all time in the field of life sciences.
The letter written by Crick to his young son showed that he was aware of the importance of the discovery. It was sold for $ 6,05M including premium by Christie's on April 10, 2013.
The Nobel Prize in Physiology or Medicine was awarded to Crick, Watson and Wilkins in 1962. Crick's Nobel medal and diploma were sold as a single lot for $ 2,27M including premium by Heritage on April 11, 2013.
Watson, now 86 years old, entrusted Christie's to sell his Nobel memories, offered in three lots on December 4 in New York. The Nobel medal with its case is estimated $ 2.5M, lot 1. His handwritten notes for the acceptance speech are estimated $ 300K,lot 2.
The manuscript of his Nobel lecture on the role of RNA in protein synthesis is estimated $ 200K, lot 3. Less than ten years after the discovery of the double helix, this theme highlighted the fact that the physicochemical mechanisms of life were already fully explained.
A portion of the proceeds from the sales will be donated by Dr. Watson to the benefit of scientific research and charities.
RESULTS INCLUDING PREMIUM
medal : $ 4.8M
speech : $ 365K
lecture : $ 245K
Scientists had identified two types of acids, RNA (ribonucleic acid) in the cytoplasm of the cell and DNA (deoxyribonucleic acid) in the chromosomes. They appreciated that these acids held the key to the functioning of life.
Two British laboratories of crystallography worked collaboratively. Francis Crick, assisted by the young US doctor James D. Watson, was at Cambridge. In London, Maurice Wilkins was assisted by Rosalind Franklin who perfected the techniques of observation and realized the radiograms. The untimely cancer of Rosalind Franklin is probably due to an excess of radiation dose.
The single helix of RNA structure and the two strands of DNA were among the first discoveries. In 1953, Watson understood that the shapes of the elements of the two DNA strands were identical although these elements were different. Crick and Watson immediately developed the model of the double helix, which was the biggest breakthrough of all time in the field of life sciences.
The letter written by Crick to his young son showed that he was aware of the importance of the discovery. It was sold for $ 6,05M including premium by Christie's on April 10, 2013.
The Nobel Prize in Physiology or Medicine was awarded to Crick, Watson and Wilkins in 1962. Crick's Nobel medal and diploma were sold as a single lot for $ 2,27M including premium by Heritage on April 11, 2013.
Watson, now 86 years old, entrusted Christie's to sell his Nobel memories, offered in three lots on December 4 in New York. The Nobel medal with its case is estimated $ 2.5M, lot 1. His handwritten notes for the acceptance speech are estimated $ 300K,lot 2.
The manuscript of his Nobel lecture on the role of RNA in protein synthesis is estimated $ 200K, lot 3. Less than ten years after the discovery of the double helix, this theme highlighted the fact that the physicochemical mechanisms of life were already fully explained.
A portion of the proceeds from the sales will be donated by Dr. Watson to the benefit of scientific research and charities.
RESULTS INCLUDING PREMIUM
medal : $ 4.8M
speech : $ 365K
lecture : $ 245K
1962 Award for the Double Helix
2013 SOLD 2.27 M$ including premium
The progress in the crystallographic analyses of molecules enabled the greatest scientific discovery of the last century. In 1953, by inspecting the X-ray photographs of components of biological cells, two researchers at Cambridge, England, built the double helix model of the deoxyribonucleic acid (DNA).
Both strands of the helix are connected by regularly spaced links which are always constituted by a pair of chains in two couples of possibilities. When the strands are disjoined, the helix is restructured with organic matter for the creation of the second strand of a new double helix with the same genetic message as the original DNA molecule.
Crick and Watson knew immediately that they had found the secret of the transmission of information in biological material. With this key, molecular biology soon became a major science, leading to understand cell differentiation and biodiversity.
In 1962, the Nobel Prize in Physiology or Medicine is awarded to Crick, Watson and Wilkins. The Nobel gold medal and diploma attributed to Francis HC Crick are presented in a single lot, estimated $ 500K, in the sale organized by Heritage in New York on 10 and 11 April. Here is the link to the catalog.
Before Crick and Watson, no geometer, no artist had imagined this compact and steady structure.
POST SALE COMMENT
The result, $ 2.27 million including premium, exceeds all expectations. It was impossible to really estimate it prior to the sale because of the scarcity of Nobel medals on the market and of the importance of the scientific work rewarded by this one.
The price recorded the day before by Christie's on the letter of the scientist to his son, $ 6.05M including premium, also certainly had a positive effect on this lot.
The intrinsic beauty of the double helix is shown in the animation offered to the public domain by Wikimedia user brian0918:
Both strands of the helix are connected by regularly spaced links which are always constituted by a pair of chains in two couples of possibilities. When the strands are disjoined, the helix is restructured with organic matter for the creation of the second strand of a new double helix with the same genetic message as the original DNA molecule.
Crick and Watson knew immediately that they had found the secret of the transmission of information in biological material. With this key, molecular biology soon became a major science, leading to understand cell differentiation and biodiversity.
In 1962, the Nobel Prize in Physiology or Medicine is awarded to Crick, Watson and Wilkins. The Nobel gold medal and diploma attributed to Francis HC Crick are presented in a single lot, estimated $ 500K, in the sale organized by Heritage in New York on 10 and 11 April. Here is the link to the catalog.
Before Crick and Watson, no geometer, no artist had imagined this compact and steady structure.
POST SALE COMMENT
The result, $ 2.27 million including premium, exceeds all expectations. It was impossible to really estimate it prior to the sale because of the scarcity of Nobel medals on the market and of the importance of the scientific work rewarded by this one.
The price recorded the day before by Christie's on the letter of the scientist to his son, $ 6.05M including premium, also certainly had a positive effect on this lot.
The intrinsic beauty of the double helix is shown in the animation offered to the public domain by Wikimedia user brian0918:
1963 The Nerves of the Squid
2015 SOLD for $ 800K including premium
The knowledge of the physico-chemical functioning of life made its breakthroughs in the mid-twentieth century helped of course by the X-rays but also by the improvement of electricity and electronics.
Alan Hodgkin and Andrew Huxley are biophysicists and more exactly electrophysiologists. The new technique of the voltage clamp allows them to measure the electric signal across the membrane of a nerve cell.
The sciatic nerve of the frog did not allow measurements in a sufficient accuracy. Working in association with the marine biology laboratory of Plymouth in England, they use in their experiments the largest known axon in the animal reign, measuring 1 mm in diameter, used by the squid to elicit a quick reaction to a threat.
The two researchers can then model the electrical behavior of the neuron. This fruitful advance will have a considerable impact on the knowledge and healing of several nerve diseases and will enable to raise a model of the transmission of nerve inputs to the muscular system. The existence of ion channels in cell membranes will be confirmed by others much later, completing the description of the nervous cell.
Hodgkin and Huxley shared the 1963 Nobel Prize in Physiology or Medicine with John Eccles. The Nobel medal awarded to Hodgkin will be sold with various documents including a copy of the scientific publication associated with the prize as lot 1 in an online timed auction ending on October 29. The minimum bid is $ 450K.
The auction house, Nate D. Sanders, is based in Los Angeles. It is gradually becoming a leader in the growing market for Nobel medals, with successful sales reminded below.
The Nobel Prize in Economic Sciences of Kuznets (1971) was sold for $ 390K on 26 February 2015. The Nobel Prize in Chemistry of Wieland (1927) was sold for $ 395K on 30 April 2015. The Nobel Prize in Physics of Lederman (1988) was sold for $ 765K on 28 May 2015. These prices include the premium.
Alan Hodgkin and Andrew Huxley are biophysicists and more exactly electrophysiologists. The new technique of the voltage clamp allows them to measure the electric signal across the membrane of a nerve cell.
The sciatic nerve of the frog did not allow measurements in a sufficient accuracy. Working in association with the marine biology laboratory of Plymouth in England, they use in their experiments the largest known axon in the animal reign, measuring 1 mm in diameter, used by the squid to elicit a quick reaction to a threat.
The two researchers can then model the electrical behavior of the neuron. This fruitful advance will have a considerable impact on the knowledge and healing of several nerve diseases and will enable to raise a model of the transmission of nerve inputs to the muscular system. The existence of ion channels in cell membranes will be confirmed by others much later, completing the description of the nervous cell.
Hodgkin and Huxley shared the 1963 Nobel Prize in Physiology or Medicine with John Eccles. The Nobel medal awarded to Hodgkin will be sold with various documents including a copy of the scientific publication associated with the prize as lot 1 in an online timed auction ending on October 29. The minimum bid is $ 450K.
The auction house, Nate D. Sanders, is based in Los Angeles. It is gradually becoming a leader in the growing market for Nobel medals, with successful sales reminded below.
The Nobel Prize in Economic Sciences of Kuznets (1971) was sold for $ 390K on 26 February 2015. The Nobel Prize in Chemistry of Wieland (1927) was sold for $ 395K on 30 April 2015. The Nobel Prize in Physics of Lederman (1988) was sold for $ 765K on 28 May 2015. These prices include the premium.
1993 DNA in Vitro
2016 SOLD for $ 670K including premium
Life exists because the chains of the DNA molecule have the capability to replicate. The discovery of the double helix structure by the team of crystallographers of Crick and Watson in 1953 was followed as early as 1956 by the discovery of the catalyst by a biochemist, Kornberg.
The molecular phenomena are too small to be studied individually but the challenge is immense. Genetic defects or viral attacks would be best countered if their mechanisms were modeled on the scale of the chain sequence.
The early tests for the replication in vitro of complete DNA sequences are discouraging by their processing time and their low yield. Chemists take control in their turn of that problem. In 1982, a publication by Dr. Kary Mullis working for Cetus company provides the solution, identified as PCR (Polymerase Chain Reaction).
Once the chain carrying the property to be analyzed is isolated, it is put in the presence of a nourishing primer and subjected to successive cycles of heating and cooling. The reaction is fast and the population growth is exponential. The invention of Mullis is intuitive. His great merit is to have proved the correctness of his concept by developing the appropriate machine. The impact on genetic engineering is immediate.
Mullis received the 1993 Nobel Prize in Chemistry, shared with the biochemist Michael Smith.
On February 14 in Pasadena, Bonhams sells in one lot the Nobel medal of Dr. Mullis along with his Nobel diploma, a copy of his lecture and several other documents. He is only the third Nobel winner to sell his own medal at auction, and much younger than Watson and Lederman. This set is estimated $ 450K, lot 93.
I invite you to watch the interview of Dr. Mullis by Bonhams before the preparation of the sale.
The molecular phenomena are too small to be studied individually but the challenge is immense. Genetic defects or viral attacks would be best countered if their mechanisms were modeled on the scale of the chain sequence.
The early tests for the replication in vitro of complete DNA sequences are discouraging by their processing time and their low yield. Chemists take control in their turn of that problem. In 1982, a publication by Dr. Kary Mullis working for Cetus company provides the solution, identified as PCR (Polymerase Chain Reaction).
Once the chain carrying the property to be analyzed is isolated, it is put in the presence of a nourishing primer and subjected to successive cycles of heating and cooling. The reaction is fast and the population growth is exponential. The invention of Mullis is intuitive. His great merit is to have proved the correctness of his concept by developing the appropriate machine. The impact on genetic engineering is immediate.
Mullis received the 1993 Nobel Prize in Chemistry, shared with the biochemist Michael Smith.
On February 14 in Pasadena, Bonhams sells in one lot the Nobel medal of Dr. Mullis along with his Nobel diploma, a copy of his lecture and several other documents. He is only the third Nobel winner to sell his own medal at auction, and much younger than Watson and Lederman. This set is estimated $ 450K, lot 93.
I invite you to watch the interview of Dr. Mullis by Bonhams before the preparation of the sale.
