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Ancient Science

Except otherwise stated, all results include the premium.
​See also : Sciences  Paleography  Incunabula  Astronomy  Medicine  Computing  16th century books  Autograph
​Chronology : 16th century  1500-1519

second half 10th century  the Archimedes Palimpsest
1998 SOLD for $ 2.2M by Christie's

Parchment was expensive and religious writings had nevertheless to be released on a durable support. The copyists of the Middle Ages made palimpsests, which we could also refer as cannibalizations. They erased the original text by scraping or wetting it and then wrote over it. Many antique texts were thus lost because their support was still in good condition.

Sometimes the deleted text reappears after several centuries because its ink has permeated the parchment. The original writing of a palimpsest on vellum which was kept in a religious library in Constantinople is correctly identified in 1906 as a scientific treatise by Archimedes.

The upper manuscript is a liturgical work in Greek copied in the 12th century. The scribe has carefully reused the leaves from a thick codex on which he has written his text at 90° to the original text before folding each page into a bifolium for a total of 177 sheets 20 x 15 cm.

The photo below gives the example of an unfolded bifolium on which the two writings are perfectly visible at 90° to each other. The copyright of this image shared by Wikimedia is held by the Walters Museum of Baltimore with a reference to their site dedicated to the palimpsest.

The Archimedes palimpsest resurfaced in 1996 in fairly poor condition, with three missing pages and four pages made illegible by modern illustrations. It was sold for $ 2.2M by Christie's on October 29, 1998, lot 1.

The original texts were studied in detail before the sale, and still more since the sale with the most modern imagery techniques by a team from the Walters Art Museum where the new owner deposited the book.

Written in Greek most probably in Constantinople in the second half of the 10th century, they consist of seven scientific treatises by Archimedes, two of which were previously unknown, plus a few pages from an antique Greek orator.

The previously unpublished texts provide a new and incomparable vision on the scientific method of Archimedes, specifically when he compares volumes and surfaces, constituting didactic puzzles which anticipate by nearly two millennia the modern methods of analysis.
Picture
Paleography

Historia Naturalis by PLINY (Plinius Secundus)
Intro

The intense and interdisciplinary curiosity of the fifteenth century anticipates the printing. Pope Nicholas V, who died in 1455, is developing a library that will be formalized 20 years later under the name of Bibliotheca Apostolica Vaticana. All types of knowledge are now welcomed.

Asking Grok to identify the printed book as a breakthrough for the dissemination of knowledge in the 1470s. Include in that review Pliny (an example for sale by Sotheby's on December 9, 2025, lot 19) and Aristotle (an example sold by Bonhams on June 8, 2016, lot 1).

The Printing Press as a Breakthrough in Knowledge Dissemination: Focus on the 1470s
The invention of the movable-type printing press by Johannes Gutenberg around 1440 marked a pivotal technological revolution, but its true breakthrough as a tool for the mass dissemination of knowledge crystallized in the 1470s. During this decade, printing technology proliferated across Europe—from established hubs like Mainz and Rome to emerging centers in Paris, Lyon, Barcelona, Frankfurt, and beyond—enabling the rapid production and distribution of books on an unprecedented scale. This expansion slashed book prices by up to two-thirds between 1450 and 1500, democratizing access to texts previously confined to elite monasteries and wealthy patrons through labor-intensive manuscript copying. The result was a seismic shift in intellectual life: classical works, scientific treatises, and religious texts flooded markets, fostering the Renaissance's rebirth of learning, accelerating the Reformation's doctrinal debates, and laying the groundwork for modern science by standardizing and preserving knowledge against the errors inherent in handwritten copies. By 1480, over 110 European cities hosted presses, creating an "invisible web" of scholarship that transcended borders and social classes, transforming knowledge from a scarce commodity into a shared resource.
This era's impact is vividly illustrated by two landmark incunabula (early printed books produced before 1501), both exemplars of how printing revived ancient authorities like Pliny the Elder and Aristotle, whose ideas on natural history and philosophy had shaped Western thought for centuries. These volumes not only preserved but amplified their authors' legacies, influencing fields from biology to cosmology.
Pliny the Elder: Historia Naturalis (Rome: Sweynheym and Pannartz, 1470)
Pliny's encyclopedic Natural History—a 37-volume compendium of Roman-era knowledge on astronomy, botany, zoology, and more—epitomized the 1470s printing boom's role in reviving classical science. Printed on luxurious vellum by Conrad Sweynheym and Arnold Pannartz, the pioneering German printers who established Europe's first press in Rome's Benedictine monastery of Subiaco in 1465, this edition was one of the decade's grandest productions. Limited to just 100 copies (with around 50 on vellum), it featured meticulous two-color rubrication, illuminated initials, and a clean Roman typeface, bridging medieval manuscript traditions with print's efficiency. Priced at an astronomical 25 gold florins—equivalent to a year's wages for a skilled worker—it targeted scholars and institutions, yet its standardized text corrected centuries of scribal corruptions, ensuring reliable dissemination of Pliny's empirical observations (e.g., on minerals and exotic animals) to Renaissance naturalists like Leonardo da Vinci.
A rare vellum copy from this edition, known as the Macclesfield copy (named for its provenance in the Earl of Macclesfield's library), highlights printing's enduring value. Acquired by collector Barry Yampol (1937–2023), whose dual passions for minerals and rare books mirrored Pliny's own encyclopedic scope, it will be offered for sale by Sotheby's on December 9, 2025, as lot 19 in The Library of Barry Yampol: A First Selection, Part 1. This auction, held in New York, underscores the book's status as a cultural artifact: its pristine condition, with original binding and provenance tracing to 16th-century English nobility, positions it as a tangible link to the 1470s' knowledge explosion. Estimated in the high six figures, it exemplifies how early printed editions continue to command premium prices, reflecting their role in perpetuating Pliny's "wonder cabinet" of the natural world.

In reviewing such works, the 1470s emerge not as printing's origin but its apotheosis—a decade when the press evolved from novelty to engine of enlightenment. Pliny and Aristotle's editions, through their survival and market allure, remind us that this breakthrough wasn't merely mechanical; it was profoundly human, amplifying voices from antiquity to ignite Europe's intellectual fire. As these volumes change hands at auction, they reaffirm printing's legacy: knowledge, once fragile, became indelible.

1
​1469 Venice edition
2025 SOLD for £ 880K by Christie's

A copy of the first edition, 355 leaves printed in Venice in 1469 in Royal folio 39.4 x 26.5 cm, was sold for £ 880K from a lower estimate of £ 400K by Christie's on July 9, 2025, lot 46.

Compare Pliny's Natural History first edition printed in 1469 by Johannes de Spira, a copy of which was sold by Christie's on July 9, 2025, lot 46, with second edition, a copy of which is for sale by Sotheby's on December 9, 2025, lot 19. The Spira edition is stated as error ridden in Sotheby's catalogue : is it a fair statement ? Do you confirm that very few books had been printed in Venice before 1470 ?

Comparison of the Editions
​
Pliny the Elder's Historia naturalis (Natural History), a monumental 37-book encyclopedia compiling ancient knowledge on topics from cosmology to zoology, was one of the first classical scientific texts to enter print. The two editions in question represent the pioneering editio princeps (first printed edition) and its immediate successor, both from 1469, marking the explosive early growth of printing in Italy. Below, I compare them across key dimensions, drawing on historical production details, textual characteristics, and auction context. Note that the "second edition" is dated 1470 in some catalogs (likely due to calendar variations or colophon discrepancies), but it is universally recognized as the 1469 successor to the Venice printing.
AspectVenice
Printers & Location
Venice : Johannes de Spira (from Speyer, Germany), the first printer in Venice. Established printing in this major mercantile hub in early 1469, granted a five-year monopoly by the Venetian Senate on September 18, 1469. De Spira died later that year, leaving his brother Vindelinus to complete unfinished works.
Rome : 
Conrad Sweynheym and Arnold Pannartz (from Mainz and Cologne, Germany), the first printers in Italy (starting at Subiaco Abbey in 1465 before moving to Rome in 1467). They operated under papal patronage, editing classics for a scholarly audience.
Production Details
Venice : Folio format (ca. 404 x 281 mm); 432 leaves; Roman typeface (one of the earliest non-Gothic types). Printed in an edition of 100 copies over three months, finished before September 18, 1469. One of only three books from de Spira's press (preceded by two Cicero editions).
Rome : 
Folio format (similar dimensions); 260 leaves; proto-Roman typeface (influenced by humanist scripts). Edition size ca. 225–300 copies. Edited by Giovanni Andrea Bussi, Bishop of Aleria, with a dedicatory preface to Pope Paul II. Printed on paper, but the Sotheby's copy is exceptionally rare—on vellum (animal skin), formerly from the Earl of Macclesfield's library.
Textual Basis & Accuracy
Venice : Based on a single, corrupt medieval manuscript (likely a 12th-century recension). Contains numerous typographical and transcriptional errors due to rushed production and limited proofreading in printing's infancy. Modern scholars (e.g., John F. Healy) describe it as "distinctly imperfect," with omissions, garbled passages, and inconsistencies reflecting the source's flaws. No editorial interventions; prioritizes speed over fidelity.
Rome : 
Also derived from medieval manuscripts but benefits from Bussi's scholarly oversight—he collated multiple sources and added corrections. Fewer printing errors than the Venice edition, though not flawless (Bussi's methods drew contemporary criticism for liberties like inserting prefaces). Represents a step forward in textual restoration, influencing later editions.
Significance
Venice : The absolute
editio princeps of Pliny and the third book printed in Venice, kickstarting the city's dominance in incunabula (early printed books). Symbolizes printing's rapid spread to trade centers; its errors highlight the technology's early challenges.
Rome : 
The second printed edition overall, but the first with named scholarly editing. Part of Sweynheym & Pannartz's influential Roman series (ca. 50 titles), which elevated printing as a humanist tool. The vellum copy elevates its status as a luxury artifact.
Auction Context (2025)
Venice : Sold at Christie's (London or New York) on July 9, 2025, as lot 46 in a fine printed books sale. Provenance likely includes early owners; estimated value in the high six figures (based on prior sales of similar copies, e.g., £300,000+ in 2017). Emphasized as a cornerstone of Venetian printing.
Rome : 
Offered at Sotheby's (London) on December 9, 2025, as lot 19 in "The Library of Barry Yampol: A First Selection, Part 1." The Macclesfield vellum copy commands premium rarity; prior vellum examples have fetched £500,000–£1M. Catalogue highlights its superiority over the "error-ridden" Venice edition.
Condition & Rarity
Venice : Surviving copies: ca. 30–40 (of 100 printed). Generally well-preserved due to large format and quality paper, but some with worming or marginalia. Christie's copy described as complete with wide margins.
Rome : 
Surviving copies: ca. 100+ (of 225–300), but vellum variants: fewer than 10 known. Sotheby's copy in fine condition, with historical provenance enhancing value. Vellum's durability and luster make it a collector's prize.

In summary, the Venice edition is a raw milestone of technological innovation—hasty, flawed, but foundational—while the Rome edition embodies emerging scholarly rigor, with better (though imperfect) textual handling. Both fueled the Renaissance revival of classics, but the Rome printing's editorial layer makes it more reliable for study, whereas the Venice one's scarcity and "firstness" drive its appeal.
Is the Sotheby's Statement That the Spira Edition Is "Error-Ridden" Fair?
Yes, this is a fair and well-substantiated assessment, though slightly hyperbolic for rhetorical effect in an auction catalogue. The Spira edition's errors stem from its reliance on a degraded manuscript tradition (9th–12th century recensions rife with interpolations and lacunae) and the primitive state of printing: no standardized proofreading, manual type-setting prone to slips, and de Spira's focus on volume over accuracy amid Venice's booming demand. Scholarly consensus, including the Incunabula Short Title Catalogue (ISTC ip00760000) and analyses by philologists like John Monfasani, confirms hundreds of minor errors (e.g., misspellings, omitted words) and major textual corruptions (e.g., garbled scientific descriptions in Books 10–11 on animals). Healy's "distinctly imperfect" label in his 1991 Loeb translation underscores this.
That said, "error-ridden" isn't unique to Spira—early incunabula across Europe averaged 1–2 errors per page due to the medium's novelty. The Rome edition, while superior, faced its own critiques: Bussi was accused by Niccolò Perotti (ca. 1470) of hasty emendations and fabricating prefaces, sparking the first calls for printing censorship. Sotheby's phrasing serves to spotlight the Rome copy's refinements, but it aligns with bibliographic reality: the Spira text required corrections in subsequent editions (e.g., Jenson's 1472 Venice printing). In auction terms, it enhances the lot's narrative without misleading.
Confirmation: Very Few Books Printed in Venice Before 1470
​
Yes, I confirm this emphatically—printing in Venice was extraordinarily nascent before 1470. De Spira's press, operational from early 1469, produced exactly three books that year:
  1. Cicero's Epistolae ad familiares (first edition, 100 copies).
  2. Cicero's Epistolae ad familiares (second edition, 300 copies).
  3. Pliny's Historia naturalis (100 copies).
De Spira began a fourth (Augustine's De civitate Dei), completed posthumously by Vindelinus de Spira in 1470. No other presses existed in Venice until 1470, when competitors like Nicolaus Jenson arrived. This totals under 600 copies across all titles, a minuscule output compared to Venice's later explosion (ca. 4,500 incunabula editions by 1501, over 1 million copies). The city's pre-1470 scarcity reflects printing's migration from Germany (Mainz, 1450s) to Italy, with Venice's monopoly patent underscoring its experimental phase. No evidence exists of pre-1469 printing there, confirming "very few" (in fact, a mere trio).

2
​1469-1470 Rome edition
2025 SOLD for $ 1.27M by Sotheby's

The second edition of Pliny's Historia Naturalis was printed in about 300 copies in Rome in 1469-1470, very soon after the first error-riddled edition printed in Venice.

An illuminated copy on 38 x 27 cm vellum folio was sold for $ 1.27M from a lower estimate of $ 900K by Sotheby's on December 9, 2025, lot 19. It is 
rubricated throughout in red and blue.

In the same sale from the same collection, a copy of the first edition in Italian, printed in 1476 in Venice by Nicolaus Jenson, was sold for $ 356K, lot 20.
Incunabula

1502 Summa by Pacioli
​2019 SOLD for $ 1.21M by Christie's

Born in Tuscany, Luca Pacioli receives a trade-oriented education. He meets (probably in Urbino) Piero della Francesca who was born in the same borgo as him. Piero is one of the most eclectic spirits of the Renaissance, able to integrate into his theories both mathematics and pictorial art.

Luca settles permanently in Venice in the 1470s as a Franciscan friar. Venice is a city of merchants. He reads the works of his most important predecessors including Fibonacci. He continues to teach and prepares a compilation of the whole knowledge in terms of arithmetic, geometry and study of proportions, to which he adds the best accounting practices of the Venetian trade.

In the best tradition of the antique and Arabic science which includes for example Euclid, Aristotle, Ptolemy and Avicenna, Pacioli is a compiler. He relies among other sources on the Liber Abaci prepared in 1202 by Fibonacci, which demonstrated that the Indo-Arabic numbering system is much better than the Roman numerals.


Pacioli does not omit anything about arithmetic and its applications. He promotes the double entry bookkeeping already practiced by some merchants, separating the recordings of debit and credit. He illustrates the position of fingers to identify high numbers in the decimal system. He defines the perfect proportions in the arrangements of elementary geometrical figures.

Luca writes his textbook in Italian and not in Latin, to ensure that it will be well understood by the merchants. His book titled Summa di arithmetica, geometria, proporzioni e proporzionalita, published in Venice in 1494, is the first arithmetic treatise in the vernacular. Of middle class origin, Pacioli wants above all to provide a guide of good practices for the merchants.

He succeeded beyond all hope. Merchants follow his recommendations, constantly maintaining a situation analysis of their business. The clarity of their accountings puts an end to the mistrust of their clients.

A copy announced in superb condition of the first issue of the first edition in its original binding was sold for € 550K by Finarte on June 20, 2019. lot 507.

Leonardo da Vinci buys in  the following year a copy from the same issue. Without doubt at his request, Luca joins the court of Ludovico Sforza in Milan in 1496. The collaboration of the mathematician and the artist is early interrupted by the wars of Italy but it is fruitful, deepening and applying the concept of golden ratio. Paganinus publishes their joint work in 1509 in Venice under the title Divina proporzione. Leonardo reuses in his Last Supper the geometrical principles proposed by the mathematician. A direct influence by Pacioli on Dürer is also very likely.

On June 12, 2019, Christie's sold for $ 1.21M at lot 1 a complete copy of the second issue of the first edition, printed circa 1502 by Paganinus after a few typographical reworks. This book is in its original state : it was not trimmed and has kept its period vellum wrapper. Please watch the video shared by the auction house.

The remarkable story of a Renaissance book described as ‘the most influential work in the history of capitalism’. Summa de Arithmetica by #LucaPacioli will be offered in #NewYork on 12 June https://t.co/3RHX5Ca3kZ pic.twitter.com/ERxXY9fmhe

— Christie's (@ChristiesInc) May 24, 2019

This June 12 we will offer at auction Luca Pacioli’s Summa de Arithmetica: The Birth of Modern Business in #NewYork. Known to represent "the pinnacle of mathematical knowledge in the Renaissance" Pacioli's book is considerably an icon of the history of all human knowledge. pic.twitter.com/RYSyANDl4V

— Christie's (@ChristiesInc) February 21, 2019
Computing

1505 Ottoman Astrolabe
2014 SOLD for £ 960K by Sotheby's

The map of the respective positions of the stars is immutable although the absolute position varies with latitude, altitude and time. The position of the sun also meets strict rules. The astrolabe is an instrument of very high complexity which allows to correlate all these variables in measurements of great accuracy.

Invented a little more than 2,000 years ago, the astrolabe is the computer of the sky. This ancient star tracker measured the time by locating the position of the sky, provided you know the latitude and, to a lesser extent, the altitude. 


The astrolabe was described for the first time around 550 CE in Alexandria but its improvement is essentially the work of the Muslim astronomers. Nearly all celestial phenomena were used as references or studied : solstices, equinoxes, eclipses, planet motions. The precision was so high that the error brought ​​by the precession of the equinoxes can now be used to date the instrument. 

In the 10th century an enthusiastic theorist listed about 1,000 different uses of this truly universal instrument, in the etymological meaning of 'universal'. In seeking the knowledge of the sky, astronomers also aimed at astrology and watched the zodiacal signs. 

This instrument of very high complexity in its geometrical design and of remarkable sharp engraving reached an angular accuracy around one degree.

​The use of the astrolabe extends of course to all the Muslim world as far as Spain, but the most advanced theoretical and practical treatises remain the work of the astronomers of the Middle East.


The ibn al-Saffar brothers worked in Cordoba at the beginning of the 5th century of the Hegira. Ahmed is a very important teacher whose writings will be used for four centuries. Muhammad makes the instruments.

Three astrolabes signed by Muhammad ibn al-Saffar are known. The earliest, dated 411AH corresponding to 1020/1021 in our calendar, was sold for £ 610K by Sotheby's on April 26, 2017, lot 170. It is a big piece 19 cm overall including the suspension loop.

This astrolabe is complete but not entirely original, for a valid reason. Indeed the rete which simulates the map of the sky becomes obsolete after a few decades due to the precession of the equinoxes. The ancient users were aware of this phenomenon and the rete of this instrument was changed in Ottoman Turkey. The position of one of its star pointers suggests a date around 1550 of our calendar for this replacement part.

The mater is the rear side of the instrument. This one is set to the 66° latitude corresponding to the longest day time known by the astronomers in the Antiquity. Six original double-sided removable plates are joined with the indication of latitudes and cities, inviting for a fabulous journey into the medieval Muslim world. From South to North : Yemen, Mecca, Medina, Cairo, Qairawan, Damascus, Malaga, Cordoba, Toledo, Zaragoza.

The astrolabe quadrant was invented ca 1288 by a French Jewish medical doctor and scientific translator. The earliest known of eight surviving examples was sold for £ 730K by Christie's on December 11, 2019, 
lot 1. It had been made between 1291 and 1311 CE, possibly in Montpellier.

Muslim science proceeds by accumulating knowledge, following the antique science. On 
March 31, 2021, Sotheby's sold for £ 740K from a lower estimate of £ 600K an astrolabe mixing Western and Arab influences, lot 66.

The instrument is dated 737 AH corresponding to 1336-37 CE. It is signed by a craftsman who is not known elsewhere but whose name is significant, Ahmad ibn Abi 'Abdallah al-Qurtubi al-Yamani, located in Tudela, a Navarrese town between Pamplona and Zaragoza. The author's name means that he is of Yemeni origin but had resided in Cordoba, thus combining two of the main centers of production of the astrolabes.

The 12 cm diameter instrument is made of brass. All components except the mater have been gilded, probably later. The alidade, which is used to measure the position of the stars, is missing.

Only one plate has survived. It is for the use of Cordoba with a latitude of 38° 30'. The gap under the rete leaves a place for a second plate. The rete is ornamental although its star pointers are in the pragmatic comma shape, according to Eastern practice.

The throne which carries the suspension holes is in Sevillian style. The structure of the rete seems to be of European inspiration. The choice of the star catalog is Western. The inscriptions are in an elegant mixed Andalusi Kufic script.
Sultan Bayezid II encouraged astronomy. Two astrolabes made ​​for the use of his court are known. One of them was sold for £ 960K from a lower estimate of £ 800K by Sotheby's on October 8, 2014, lot 135. 

This brass instrument of 9.5 cm diameter is complete with all its fixed and rotating parts. The knob for the rotation on the central axis is later. 

This astrolabe is indeed a masterpiece of Ottoman science, with numerous engraved inscriptions and reduced decoration. The choice of the reference star is made ​​by the user among no less than fifteen star pointers. 

It is signed and dated 911 AH, corresponding to 1505 to 1506 CE. The fact that the author is not otherwise recorded just means that he did not write a treatise.

1510 The Codex Leicester of Leonardo da Vinci
1994 SOLD for $ 31M by Christie's

From 1475 Leonardo da Vinci recorded everyday all his ideas about the nature of the world in its whole variety, in the form of notes in ancient Italian language illustrated with sketches. In this polygraphic bulimia, he accumulated about 13,000 pages, on double-sided sheets folded in half.

Leonardo is neither a scientist nor an engineer in the modern meaning of these terms. He does not waste his time analyzing the consequences of his theories or conceiving the realization of his inventions. In his swarming of ideas, he could be wonderfully right and naively wrong, and he was certainly unable to distinguish between these two extremes.

For this left-hander, the mirror writing is the way he has found so that his thinking is not slowed down by his hand. The use of numerous abbreviations, which makes these texts extremely difficult to decipher, is consistent with this hypothesis. We will never know how he desired exploiting such a unique mass of informations.

These writings were later assembled into notebooks, identified under the more technical term of codex. The Codex Leicester is the only one remaining in private hands. It was sold by Christie's for $ 5.1M on December 12, 1980 and for $ 31M on November 11, 1994. Between these two sales it was named the Codex Hammer. It was bought by Bill Gates at the last auction. The image is shared by Wikimedia.

The Codex Leicester is made up of 18 double sheets of parchment for a total of 72 pages 22 x 30 cm. It brings together his notes written around 1510 on the theme of the water movements. The author imagines that his ideas could be used for the design of bridges.

His observation on the presence of fossils in the mountains brings an explanation far ahead of his time : they were originally in a seabed which was raised by a geophysical phenomenon. This hypothesis is all the more remarkable since the monotheistic religions of his time do not question the creationism.

In the same notebook, he explains the luminosity of the Moon by the reflection of sunlight on its surface entirely covered with water.
​Leonardo da Vinci : inspirations, breakthroughs. Legacy in art, science and culture.

Leonardo da Vinci (1452–1519) stands as one of history's greatest polymaths, embodying the Renaissance ideal of the "universal man." Born in Vinci, Tuscany, he excelled across painting, drawing, sculpture, anatomy, engineering, architecture, optics, hydrodynamics, and more. His curiosity-driven approach—observing nature meticulously and blending empirical study with imagination—defined his work.
Inspirations
Leonardo drew inspiration from diverse sources that fueled his interdisciplinary genius:
  • Nature and the Tuscan landscape — Growing up in rural Vinci, the hills, rivers, and wildlife sparked his lifelong fascination with natural phenomena, from water flow to bird flight and human anatomy.
  • Classical antiquity — He studied ancient texts, notably Vitruvius's De Architectura, which influenced his famous Vitruvian Man drawing exploring ideal human proportions based on Roman architectural principles.
  • Mentors and contemporaries — As an apprentice in Andrea del Verrocchio's Florence workshop (around 1466–1476), he absorbed technical skills in painting, sculpture, and mechanics. Patron Lorenzo de' Medici exposed him to humanist circles, philosophy, and classical learning. He also engaged with (and rivaled) figures like Michelangelo.
  • Scientific observation — Leonardo rejected purely book-based knowledge, prioritizing direct experience—dissecting cadavers, experimenting with optics, and studying motion—to understand the world.
These influences encouraged him to see connections between art and science, famously stating that painting was a form of philosophy.
In science and invention:
  • Anatomy — Conducted over 30 human dissections, producing highly accurate drawings of muscles, bones, organs, and systems (e.g., heart valves, fetus in womb) that corrected ancient errors and anticipated modern understanding.
  • Engineering and mechanics — Designed concepts for machines including ornithopters (flying machines with flapping wings), a helical airscrew (early helicopter prototype), parachute, armored tank, giant crossbow, self-supporting bridge, and diving equipment.
  • Hydraulics and geology — Advanced understanding of water flow, erosion, and fossils; proposed accurate explanations for Earth's geological history.
  • Optics and other fields — Studied light refraction, camera obscura principles, and even early ideas in astronomy and mathematics.
Many inventions remained sketches due to technological limits or his perfectionism, but they demonstrated profound foresight.
Sketches of flying machines are showcasing his engineering imagination.
​
Legacy in Art, Science, and Culture
Leonardo's impact endures profoundly:
  • Art — His techniques (sfumato, perspective, emotional realism) influenced the High Renaissance and later movements. The Mona Lisa and Last Supper rank among the most famous and analyzed artworks ever, symbolizing mystery and mastery.
  • Science — His notebooks (over 7,000 pages, written in mirror script) reveal prescient insights in anatomy, engineering, and natural philosophy. Though unpublished in his lifetime, they anticipated developments in fields like fluid dynamics, aeronautics, and cardiology.
  • Culture — He epitomizes the Renaissance humanist ideal: curiosity, interdisciplinary thinking, and blending beauty with knowledge. Today, he inspires innovators in STEAM (Science, Technology, Engineering, Arts, Math), bio-inspired design, and creative problem-solving. His life represents the pursuit of universal understanding, influencing education, museums, literature (e.g., The Da Vinci Code), and popular views of genius.
Leonardo once wrote: "Learning never exhausts the mind." His relentless quest continues to motivate centuries later.
Vinci - Hammer 2A
Sciences
Autograph
16th century
Years 1500-1519

1540 De Libris Revolutionum by Rheticus
​2016 SOLD for £ 1.8M by Christie's

The intense curiosity of the fifteenth century, facilitated by the printed books, generated the modern science. The most advanced universities teach mathematics beside philosophy, theology, law and medicine. Disseminated from Bologna to Vienna or Krakow, humanists exchange new theories together.

Georg Joachim Rheticus was fond of astronomy, perhaps as a result of the appearance of the comet of 1531. He enrolled at the University of Wittenberg led by Melanchthon, the theoretician of Lutheranism.

As early as 1536, Rheticus was appointed professor of mathematics. Barely released from astrology, astronomy was at that time a branch of mathematics. The learned calculations made by Regiomontanus in the previous century had fruitfully revived the speculation about the true movements of the planets.

Two years later, Melanchthon allows Rheticus to suspend his teaching for a tour of Europe where he will visit the humanists. He hears of an old canon who spent his lifetime improving his astronomical calculations at such a point to solve the old issue of the motion of Earth, discussed since antiquity.

Rheticus so becomes the assistant to Copernicus in Frauenburg (Frombork). For nearly thirty years, the canon had refined the text of his demonstration of the heliocentric system, sometimes sending manuscripts to the very few scholars able to understand it. He does not think to edit because of an obvious difficulty to print his figures.

Rheticus supports Copernicus with enthusiasm. The younger scientist prepares a comprehensible summary with the agreement of the master. Printed in Gdansk in 1540, that 'De libris revolutionum ... narratio prima' is the first report ever published on heliocentrism. The theory is clearly and fully attributed to Copernicus without indicating the name of his efficient collaborator.

This first edition is extremely rare. A copy was sold for £ 1.8M from a lower estimate of £ 1.2M by Christie's on July 13, 2016, lot 87.

13 juillet Vente des livres scientifiques de la bibliothèque Beltrame Consultez le catalogue https://t.co/akp7LGW1ji pic.twitter.com/CtcSeM2uMW

— Christie's Paris (@christiesparis) July 1, 2016
Astronomy
16th century Books

1543 De Revolutionibus by Copernicus
2008 SOLD for $ 2.2M by Christie's

The exact title was "Nicolai Copernici Torinensis De Revolutionibus orbium coelestium." It was printed in 1543 and appeared just before the author's death. Torun was the name of his hometown. This book forever changed the ideas we had of the universe

Of relatively small size (20 x 27 cm, 202 pages), it is illustrated with woodcuts and tables of calculations.

A copy of the first edition was sold for $ 2.2M from a lower estimate of $ 900K by Christie's on June 17, 2008. In its flexible binding of same period, it was part of a prestigious library during the seventeenth century.

De Humani Corporis Fabrica by VESALIUS

1
1543 1st edition
1998 SOLD for $ 1.65M by Christie's

Andries van Wesel, who latinized his name as Andreas Vesalius, was one of the founders of modern science and one of the scientists whose work had the greatest impact on our civilization. He is the explorer of the human body.

Born to a family of doctors, he observed the decomposed corpses on the gibbet of Brussels, in front of his home. He early appreciated that only direct observation could lead to a suitable understanding.

Not only he refuted all the errors of Galen which had prevented the progress of medicine and surgery, but also he explained the reason why : in order not to defy the taboos of the Roman Empire, Galen had dissected monkeys. An example among so many progresses is the analysis of breathing by which Vesalius paves the way for life saving ventilation.

His drawings are plagiarized and challenged. Vesalius therefore decides that he must collect his observations and figures in a masterly work. After four years of preparation, De  Humani Corporis Fabrica 'libri septem' (meaning in seven books) is published in Basel in folio format 43 x 28 cm in 1543. 

The anatomical drawings were prepared in Venice by an anonymous artist, probably from Titian's studio. Some vitality was added by staging écorchés and skeletons in landscapes of the Padua countryside.

A copy owned by the Emperor Charles V, considered to be his dedication copy, was sold by Christie's on March 18, 1998 for $ 1.65M from a lower estimate of $ 400K, lot 213. All illustrations including initials had been colored with highlights in liquid gold and silver.

A copy de-accessioned from the Royal Institution was sold for £ 255K by Christie's on December 1, 2015, lot 284. It passed at Sotheby's on July 11, 2024, lot 115.

2
1555 annotated 2nd edition
2024 SOLD for $ 2.23M by Christie's

The second Basel edition of the De humani corporis fabrica was issued in 1555 with new types in the same folio format 43 x 28 cm. Vesalius used a printed copy for preparing an up-issue in a search for improving the clarity of his learning. This copy with about 1,000 autograph marginalia was sold for $ 2.23M from a lower estimate of $ 800K by Christie's on Febtuary 2, 2024, lot 75. Please watch the video shared by the auction house.

That project of a 3rd edition will not go further.

□ Vesalius’s own annotated copy of the second edition of his groundbreaking anatomical atlas, De humani corporis fabrica—with corrections for the never-realized third edition. Lot 75 of our upcoming online sale, from Jan 17 to Feb 2. More here: https://t.co/i1w1BDG7Bs pic.twitter.com/QObkEKiHJE

— Christie's Books (@ChristiesBKS) January 11, 2024
Medicine
Sciences 1600-1800
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