The molecular phenomena are too small to be studied individually but the challenge is immense. Genetic defects or viral attacks would be best countered if their mechanisms were modeled on the scale of the chain sequence.
The early tests for the replication in vitro of complete DNA sequences are discouraging by their processing time and their low yield. Chemists take control in their turn of that problem. In 1982, a publication by Dr. Kary Mullis working for Cetus company provides the solution, identified as PCR (Polymerase Chain Reaction).
Once the chain carrying the property to be analyzed is isolated, it is put in the presence of a nourishing primer and subjected to successive cycles of heating and cooling. The reaction is fast and the population growth is exponential. The invention of Mullis is intuitive. His great merit is to have proved the correctness of his concept by developing the appropriate machine. The impact on genetic engineering is immediate.
Mullis received the 1993 Nobel Prize in Chemistry, shared with the biochemist Michael Smith.
On February 14 in Pasadena, Bonhams sells in one lot the Nobel medal of Dr. Mullis along with his Nobel diploma, a copy of his lecture and several other documents. He is only the third Nobel winner to sell his own medal at auction, and much younger than Watson and Lederman. This set is estimated $ 450K, lot 93.
I invite you to watch the interview of Dr. Mullis by Bonhams before the preparation of the sale.
SOLD for $ 670K including premium